November 27 – 28, 2015 Grand Hotel Salerno – Sala Cilento via Lungomare Tafuri, 1, 84127 Salerno
2015/02/20 Aula F. Ferro – Polo Universitario Azienda Ospedaliera – Universitaria “San Giovanni Di Dio e Ruggi D’Aragona”…
The Bicuspid Aortic Valve Consortium (BAVCon) is an international consortium of 26 institutions gathered worldwide with cohorts of bicuspid aortic valve (BAV) patients. The members come from all medical and scientific specialties – cardiologists, radiologists, surgeons, anesthesiologists, cellular biologists and statisticians. To date, 26 Institutions with over 70 members from nine countries participate in the consortium, making this the largest group investigating bicuspid aortic valve disease. These groups have collected over 5,000 BAV patients and a similar number of “control” patients without BAV for research purposes.
The Investigators have spent years collecting BAV individuals’ radiologic studies, blood, DNA and tissue samples for analysis and have then been prospectively followed for subsequent events such as valve failure and aortic aneurysm and dissection. These cohorts have been created by investigators seeking to identify imaging or genetic variations that lead to patients experiencing to these adverse events.
Many of these cohorts are relatively small, some are larger, and on their own have limited statistical power and yield limited findings. Jointly, these cohorts and their investigators are a powerful resource to answer important questions and direct future research in BAV.
Bicuspid aortic valve (BAV) is the most common congenital cardiac abnormality affecting about 0.6 – 1.5% of individuals in the general population. It is characterized by fusion or incomplete formation of valve commissures during formation of the valve at about 8-12 weeks of gestation. Patients with BAV may also have aortic coarctation at birth, or ascending aortic aneurysm that usually develops later in adulthood. Many patients with BAV develop stenosis or incompetence of the aortic valve, usually during their 40’s to 70’s.
Despite many clinical observations obtain through years and research done on bicuspid aortic valve (BAV), not a lot it is known about the genetic basis, natural history and causative mechanisms of this disease. BAVCon‘s aim to examine these issues and perform research that improves the health of all BAV patients.